Research Interests

Research at NMCHI is organized into overlapping disease-focused research interests. All NMCHI researchers, labs and activities fall within one or more of the following programs. Each of these research interests contribute to breakthroughs in the treatment and prevention of human diseases.

Childhood Obesity and Nutrition

The Childhood Obesity and Nutrition Program at NMCHI focus on childhood obesity and nutritional intervention on the pregnancy outcome especially for women who have gestational diabetes mellitus. The research also explains the mechanism of maternal and infant exposure to environmental endocrine disruptors on childhood obesity. Plasma miRNA was applied to detect obese children forward insulin resistance and type 2 diabetes. In addition, the research explains the epigenetic regulation of early pregnancy nutrition on offspring body fat.

Child Health Care

The Child Health Care Program at NMCHI focuses on children's attention deficit hyperactivity disorder, and congenital heart disease. The research explains the mechanism of increased locomotor activity and non-selective attention and impaired learning ability in SD rats after lentiviral vector-mediated rna interference of homer1a in the brain. Roles of genes and microRNA in congenital heart disease were studied using model animal zebrafish.

Gynecologic Oncology

TheGynecologic OncologyProgram atNMCHIfocus onbreast, ovarian and cervical related tumors. The research also explains the roles of DNA methylation, microRNAs incell proliferation and apoptosis correlated with breast cancer, ovarian cancer andhysteromyoma. The function of C1q-gC1qR complex in spontaneous abortion and cervical cancer was investigated.


TheObstetrical DiseasesProgram atNMCHIfocus oneclampsia, gestational diabetes mellitusand habitual abortion. The research also explains the roles of traditional chinese medicine intherapy ofeclampsia. Proteomics analysiswas performed to identify the specific proteins in eclampsia.The research also explains the epigenetic regulation mechanism of MIF gene in dopamine neuron development in neuropathic pain. Different drugs and techniques was developed for painless labor.

Prenatal Diagnosis

The Prenatal DiagnosisProgram atNMCHIfocus on prenatal genetic diagnosis for fetal malformation using aCGH and high-throughput sequencing. The research also explains theBioTag-MStechnique in quantitative analysis of nucleic acid.

Organ Development  

TheOrgan DevelopmentProgram atNMCHI focuses onheart, eye, and skin development in various human diseases. The research also explainsthe roles of Stk40, IFRG15and miR-29b in early embryo development.